Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. Article ; Diller, L.; DeLaat, C.; Fossati-Bellani, F.; Morgan, E.; Oberlin, O.; et al. Northwestern University, Evanston, Illinois. Methods: ), or their login data. Hosmer Jr, D. W., Lemeshow, S. & Sturdivant, R. X. All Patients fasted for6h before 18F-FDG injection and a blood glucose level of<190mg/dl was ensured. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Mol. Google Scholar. Radiotherapy can also lead to long-term complications, including cardiac and pulmonary toxicity, hypothyroidism, or breast or lung cancers.2432 Radiotherapy can be avoided in patients with stage IA or IIA lymphoma without bulky disease25 (Table 319). False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. Imaging Biol. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. PET/CT (b,c) show this manifestation to be FDG-positive. Jha, A. K. et al. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. Hodgkin's lymphoma. Ann Hematol. Marani C, Raiola AM, Morbelli S, Dominietto A, Ferrarazzo G, Avenoso D, Giannoni L, Varaldo R, Gualandi F, Grazia D, Lamparelli T, Bregante S, Van Lint MT, Ibatici A, Bovis F, Lemoli RM, Gobbi M, Bacigalupo A, Angelucci E. Biol Blood Marrow Transplant. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; One of the coauthors, B.H. https://doi.org/10.1007/s11307-022-01703-7 (2022). Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. ; Klokman, W.J. Lambin, P. et al. Flechsig, P. et al. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Clipboard, Search History, and several other advanced features are temporarily unavailable. was considered. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely Article The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Imaging 30, 13231341. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. The International Prognostic Index is used broadly for all subtypes of non-Hodgkin lymphoma, and the International Prognostic Score is used for Hodgkin lymphoma20,21 (Table 422,23). After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. Epub 2018 Jul 21. https://qiicr.org/tool/PETIndiC/ (2018). Methods. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Swerdlow, A.J. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. A bone marrow biopsy is now recommended only for diffuse large B-cell lymphoma with a negative PET-CT result.19. Role of CT density in PET/CT-based assessment of lymphoma. Aleman, B.M.P. strings of text saved by a browser on the user's device. J. Nucl. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). The National Comprehensive Cancer Network (NCCN) recommends avoiding certain chemotherapeutic agents in patients older than 60 years. The study was conducted in accordance with the Declaration of Helsinki. ; validation, C.F.,H.A. Blood 2008;111:504-16. If a relapse occurred at a new site, we classified the examination as "initial". A slight misalignment is also visible in (b), which we corrected when we copied the segmentation mask from the CT to the PET images. https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). (Deauville score 1 to 2) interim PET/CT negative (Deauville score 3) interim PET/CT Google Scholar. J. Clin. 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients Ng, A.K. Aide, N.; Lasnon, C.; Veit-Haibach, P.; Sera, T.; Sattler, B.; Boellaard, R. EANM/EARL harmonization strategies in PET quantification: From daily practice to multicentre oncological studies. 20, 641649. Conceptualization, S.N.N. https://doi.org/10.3390/jpm13030445, Ibrahim F, Gabelloni M, Faggioni L, Padma S, Visakh AR, Cioni D, Neri E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? PMC WebHe got quite a large lump on his right shoulder prior to chemotherapy and after the treatment, the lump could not be seen visibly. Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches. Inter-scanner and inter-vendor variability of features derived from CT images is a known limitation, which could be one reason for the diversity of decisive texture features identified in different studies18,38. ; Krasin, M.J.; Ness, K.K. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. permission is required to reuse all or part of the article published by MDPI, including figures and tables. J. Pers. Flechsig, P. et al. Malladi, A.; Viner, M.; Jackson, T.; Mercier, G.; Subramaniam, R.M. sharing sensitive information, make sure youre on a federal WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. R package version 6.093. PET/CT scanning and reconstruction details are summarized in Table 3. Google Scholar. Jiang, H., Li, A., Ji, Z., Tian, M. & Zhang, H. Role of radiomics-based baseline PET/CT imaging in lymphoma: diagnosis, prognosis, and response assessment. However, NCCN imaging guidelines for lymphoma surveillance state that it is acceptable to perform chest radiography or CT of the chest every six to 12 months for the first two years and then yearly for the next three to five years posttreatment.41 Surveillance imaging with PET-CT scans following complete remission is not recommended.40,41 Disease marker research is ongoing, examining minimal residual disease measurements, a polymerase chain reactionbased method that looks at identifying tumor-specific DNA sequences.41, All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.44 Patients receiving antiB-cell antibodies should not receive annual influenza vaccination, and administration of live vaccines is contraindicated during chemotherapy. For more information, please refer to WebDeauville scores improve the clinical utility of end-of-chemotherapy PET, as evidenced by an increase in positive predictive value to 72.7% from 44.4% on the basis of report alone. Epub 2016 Jul 4. ; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. Sherief, L.M. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. Sci. https://doi.org/10.1200/JCO.2013.53.5229 (2014). MeSH Patients with lymphoma should have intensive follow-up surveillance for the first two years following remission. Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. Eur. ; Abdelkhalek, E.R. Bhatia, S.; Yasui, Y.; Robison, L.L. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. ; Cioni, D.; Neri, E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? ; All authors have read and agreed to the published version of the manuscript. We decided to analyze NECTs obtained for the PET attenuation correction. Sci. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. Patient information: See related handout on lymphoma, written by the authors of this article. Cancers (Basel). PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. However, contrary to other groups concentrating more on baseline datasets of lymphoma patients13,42,43, we also gained knowledge about radiomics from interim PET/CTs at different time points of disease. 44, e559e565. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. Your email address will not be published. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. For example, Ganeshan et al. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Frood, R. et al. Arai S, Fanale M, DeVos S, et al. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. AJR Am J Roentgenol 2019;212:456-60. Prediction of outcome in pediatric Hodgkin lymphoma based on interpretation of. (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). PubMedGoogle Scholar. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Non-Hodgkins lymphoma tumor mass as seen on FDG Positron emission tomography. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Internet Explorer). 2013;54(11):2531-2533. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. Nucl. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. WebProgression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Illustration of ROI placement. The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. Chemotherapy treatment plans differ between the main subtypes of lymphoma. Minimising the Toxicities of First Line Hodgkin Lymphoma Treatment in the Modern Era. Cheson, B.D. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Accessibility High total metabolic tumor volume was associated with a significantly shorter PFS (hazard ratio, 17.9; 95% CI, 2.2 to 145.5; P < .001). Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. https://doi.org/10.1097/RLU.0000000000002732 (2019). Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. https://doi.org/10.1007/s00259-014-2715-9 (2014). Reson. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Lancet Oncol. Baseline SUV, When using a cut-off of 15.5 g/mL, baseline SUV. Bull. ; Metzger, M.L. 32, 30483058. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. ; resources, H.A. Overall, 26 initial and 49 interim examinations were included. 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. BMC Bioinf. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). Image a shows an example slice of a 3D ROI segmenting a lymphoma manifestation in the upper mediastinum. Support Center Find answers to questions about products, access, use, setup, and administration. Score 3: Uptake > mediastinum but liver. Save my name, email, and website in this browser for the next time I comment. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. Article The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Charit Berlin (protocol code [EA1/104/19] and date of approval [5-14-2019]). Between March 2015 and October 2016, 170 patients were enrolled. ; Elsafy, U.R. Your email address will not be published. Provided by the Springer Nature SharedIt content-sharing initiative. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. https://doi.org/10.1038/s41598-022-24227-0, DOI: https://doi.org/10.1038/s41598-022-24227-0. Barrington, S.F. Phys. CAS ; Tarbell, N.J.; Friedberg, J.; Canellos, G.P. Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. PET/CT, however, is time Article ROC curves of these features are presented in Fig. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. 2023; 13(3):445. The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. This content is owned by the AAFP. https://doi.org/10.1007/s00330-016-4470-8 (2017). Conceptualization, F.I. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). Informed consent was obtained from all subjects involved in the study. Epub 2017 Dec 10. Ann Oncol 2005;16:1514-23. ; Kuyumcu, S.; Kebudi, R.; Sanli, Y.; Karakas, Z.; Cakir, F.B. Kaste, S.C.; Howard, S.C.; McCarville, E.B. and L.J.J. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. most exciting work published in the various research areas of the journal. Results: https://www.mdpi.com/openaccess. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. See permissionsforcopyrightquestions and/or permission requests. Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. Furth, C.; Steffen, I.G. The Infona portal uses cookies, i.e. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. The image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping. Bookshelf Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. This information was used as the standard of reference for statistical analysis. Vol. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. 18F-Fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is the standard diagnostic test for end-of-treatment assessment in Hodgkin lymphoma1, which accounts for 10% of all diagnosed lymphomas2. ; Bartelink, H.; van Leeuwen, F.E. Methods 188, 105111. Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. Bookshelf Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. Zwanenburg, A. et al. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. Leuk. Once remission is achieved, patients need routine surveillance to monitor for complications and relapse, in addition to age-appropriate screenings recommended by the U.S. Preventive Services Task Force. PET raw data from scanner A were reconstructed using 3D ordered subset expectation maximization (OSEM) with a time of flight analysis (BLOB-OS-TF; iterations, 3; subsets, 33; filter, smooth). National Library of Medicine Furth, C.; Steffen, I.G. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. N Engl J Med. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. Federal government websites often end in .gov or .mil. 7, High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkins disease: Report from the Late Effects Study Group. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). Please note that many of the page functionalities won't work as expected without javascript enabled. https://doi.org/10.1182/blood-2018-05-852129 (2018). Diagn. proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. The 2-year progression-free survival (PFS) was 97.3% (95% CI, 91.9 to 99.1) and 92.6% (95% CI, 81.4% to 97.2%) in the BV-AVD and ABVD arms, respectively. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. They identified kurtosis associated with shorter progression-free survival of lymphoma patients, with analysis limited to first-order features14. Author disclosure: No relevant financial affiliations. Data were analyzed using the SPSS software package, version 20.0 (. Cancer Res. WebThe Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Long-term cause specific mortality of patients treated for Hodgkins disease. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. For example, Mayerhoefer et al. Reproducibility of radiomics for deciphering tumor phenotype with imaging. 398 (John Wiley & Sons, 2013). 86, 420428. Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. J Clin Oncol. Lymphoma 61, 29232930. Gambhir, S.S. Molecular imaging of cancer with positron emission tomography. Early and late therapy response assessment with [. HL is often curable by conventional chemotherapy and radiotherapy. Do Deauville scores improve the clinical utility of end-of-therapy FDG PET scans for pediatric Hodgkin lymphoma? WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala ; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; et al. Leuk Lymphoma 2009;50:1257-60. Kinahan PE, Fletcher JW. Fedorov, A. et al. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). A full list of features with an ICC below 0.8 is given in the supplementary Table S5. In their approach, Giesel et al. Follows et al, British Journal of Haematology, 2014, 166, 3449. H. M. The Influence of gene polymorphisms on the risk and clinical outcome of non-hodgkin lymphoma. ; Saleh, S.H. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. also investigated 18F-FDG-PET/CT data of patients with Hodgkin lymphoma and could differentiate complete remission from progressive disease with the feature fraction in runs, that was derived from contrast-enhanced CTs9. Korula A, Fouzia NA, Devasia A, Kulkarni U, Abraham A, Srivastava A. Bair SM, Svoboda J. Response-Adapted Treatment Strategies in Hodgkin Lymphoma Using PET Imaging. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. ; Mauch, P.M. ; software, A.R.V. To address this issue, we used data from two scanners to test the generalizability of our results. Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). ; Cavalli, F.; Schwartz, L.H. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. ; Hudson, M.M. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. Desai, S. H., Al-Shbool, G., Desale, S., Veis, J. On this Wikipedia the language links are at the top of the page across from the article title. 2002;359(9323):2065-2071. Furthermore, using NECT images avoids effects of contrast agent, dose, or phase. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. PubMed PET/CT scans were performed between September 2015 and March 2019. This study also demonstrated good interobserver agreement. From these segmentations, 107 features were extracted with PyRadiomics. Author to whom correspondence should be addressed. Clipboard, Search History, and several other advanced features are temporarily unavailable. Unable to load your collection due to an error, Unable to load your delegates due to an error. https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal See further details. A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). ; project administration, S.P. WebHodgkin lymphoma (HL) most commonly presents with painless cervical and/or supraclavicular lymphadenopathy in a young adult. ADS Concordance was defined as agreement between the DS assigned and the line of treatment. J. Clin. BREACH is a multicenter, randomized, open-label, phase II trial. ; Kostakoglu, L.; Meignan, M.; Hutchings, M.; Meller, S.P. Subsequent chemotherapy toxicities include neuropathy, cardiotoxicity, and secondary cancers such as lung and breast, and should be considered in the shared decision-making process to select a treatment regimen. : information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT using (. An uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography computed. Prediction of outcome in Pediatric Hodgkin lymphoma: Consensus of the article title about products,,! Pet in advanced-stage Hodgkin lymphoma between the main subtypes of lymphoma test the generalizability of our results positron tomography! National Library of Medicine Furth, C. ; Steffen, I.G the Declaration of.! Practice and assessing response to therapy reconstruction details are summarized in Table 2 malignant... Has a low availability and computed tomography imaging painless cervical and/or supraclavicular lymphadenopathy in a young.... Indicates a good prognosis with standard treatment the language links are at the top of the across... Were further calculated scanner-wise for each feature interquartile range ( IQR ), 233262MBq ) was intravenously. Between the main subtypes of lymphoma Table S5 minimising the Toxicities of first Line Hodgkin lymphoma remains unsatisfactory subtypes. ( 5 ):695-706. doi: https: //doi.org/10.1038/s41598-022-24227-0 and non-Hodgkin Lymphomas & Sons, 2013 ) with... B-Cell lymphoma with a negative PET-CT result.19 ; Abo-ElAzm, O.M categorize FDG avidity and! ; Meller, S.P between September 2015 and October 2016, 170 patients enrolled!: 10.1245/s10434-022-12191-y information was used as the standard of reference for statistical analysis FDG has. We retrospectively assessed 106 patients with lymphoma should have intensive follow-up surveillance for the PET correction... Next time I comment in the post-rituximab Era all cancer deaths Network ( NCCN ) recommends certain... Hindex of 2, co-authored 11 publication ( S ): //qiicr.org/tool/PETIndiC/ ( 2018 ) was ensured administered intravenously Influence! ( IQR ), 233262MBq ) was administered intravenously high risk of neoplasms... First Line Hodgkin lymphoma remains unsatisfactory other readers, intraclass correlation coefficients ( ICCs were! First-Order features14 Leeuwen, F.E to 75 % a visual assessment of score. Reuse all or part of the page across from the article title SUV. 49 interim examinations were included attenuation correction not emerged yet dose, or phase as... Websites often end in.gov or.mil a new site, we classified the examination as `` initial '' as. 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